Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Deborah Preston
Tanzania
Research Article
Role of Serum Biomarkers in Early Detection of Non-Alcoholic Steatohepatitis and Fibrosis in West Virginian Children
Author(s): Komal Sodhi, Lucas Bracero, Andrew Feyh, Alexandra Nichols, Krithika Srikanthan, Tariq Latif, Deborah Preston, Joseph I Shapiro and Yoram ElitsurKomal Sodhi, Lucas Bracero, Andrew Feyh, Alexandra Nichols, Krithika Srikanthan, Tariq Latif, Deborah Preston, Joseph I Shapiro and Yoram Elitsur
Background: Obesity, an epidemic among West Virginia children, as well as insulin resistance (IR), is wellestablished contributors to nonalcoholic steatohepatitis (NASH). Progression of NASH can lead to hepatic fibrosis and cirrhosis, making early detection imperative. The standard for diagnosing NASH is histologically via liver biopsy, which is highly invasive and generally contraindicated in children. By studying serum biomarkers associated with NASH, we aim to identify high risk children who can benefit from a less invasive, alternative approach to the early detection of NASH.
Methods: Seventy one children were prospectively recruited and divided into 3 groups: normal weight without IR (control), obese without IR, and obese with IR. Serum samples were drawn for each patient and biomarker levels were assessed via ELISA kits.
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DOI:
10.4172/2155-9899.1000393