Journal of Proteomics & Bioinformatics
Open Access

Deekshi Angira

Publications

• Research Article
  Structural Investigation and In-silico Characterization of Plasmepsins from Plasmodium falciparum
  Author(s): Divya N. Nair, Vijay Singh, Deekshi Angira and Vijay Thiruvenkatam Divya N. Nair, Vijay Singh, Deekshi Angira and Vijay Thiruvenkatam
  
  Malaria is the one most important parasitic disease of humans, which affects approximately one hundred countries and threatens half of the world’s population. The Plasmodium aspartic protease called plasmepsins performs a vital role in providing nutrients to the malaria parasite, which make these proteins as an excellent drug target. In this study, we have carried out a comparative protein modeling, active site analysis and structural analysis of all ten plasmepsins from Plasmodium falciparum. In this report we have analyzed in-silico structure modeling and made efforts to characterize plasmepsins structure and further propose its functional information. The phylogenetic analysis and disulfide linkages indicate, plasmepsin I to IV and HAP have similar structure, function property. Whereas, plasmepsin IX to X and.. View More»
  DOI: 10.4172/jpb.1000405

  Abstract PDF

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