Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Denic A
Tanzania
Research Article
Profile of Circulatory Metabolites in a Relapsing-remitting Animal Model of Multiple Sclerosis using Global Metabolomics
Author(s): Mangalam AK, Poisson LM, Nemutlu E, Datta I, Denic A, Dzeja P, Rodriguez M, Rattan R and Giri S
Mangalam AK, Poisson LM, Nemutlu E, Datta I, Denic A, Dzeja P, Rodriguez M, Rattan R and Giri S
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the CNS. Although, MS is well characterized in terms of the role played by immune cells, cytokines and CNS pathology, nothing is known about the metabolic alterations that occur during the disease process in circulation. Recently, metabolic aberrations have been defined in various disease processes either as contributing to the disease, as potential biomarkers, or as therapeutic targets. Thus in an attempt to define the metabolic alterations that may be associated with MS disease progression, we profiled the plasma metabolites at the chronic phase of disease utilizing relapsing remittingexperimental autoimmune encephalomyelitis (RR-EAE) model in SJL mice. At the chronic phase of the disease (day 45), untargeted global metabolomic profiling of plasma collected from EAE diseased SJL and healthy mice was perfo.. View More»
DOI:
10.4172/2155-9899.1000150