Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Denis V Rebrikov
Institute of General Genetics of Russian Academy of Sciences,
Gubkina str., 3, Moscow, 119991
Serbia
Research Article
Association Between Alleles of Cytokine Genes with Rheumatoid Arthritis in Russian Population
Author(s): Nataliya E Soroka, Svetlana A Morozova, Valery V Ilinsky, Dmitry Y Trof mov and Denis V RebrikovNataliya E Soroka, Svetlana A Morozova, Valery V Ilinsky, Dmitry Y Trof mov and Denis V Rebrikov
Background: Rheumatoid arthritis (RA) is a multi-factor disease with a key role of genetic component in its genesis. Development of osteoporosis and articular destruction is attributed with overexpression of pro-infl ammatory cytokines and reduced production of anti-infl ammatory ones. In this work probable associations of IFN-γ, IL-1α, IL-1β, IL-4, IL-6, IL-10, IL-18 and TNFα alleles with rheumatoid arthritis were studied among Russian ethnic group. Methods: A total of 69 Russian ethnical group patients with RA (cases) and 133 healthy control individuals (controls) were genotyped for variants in 8 cytokines genes (IFN-γ, IL-1α, IL-1β, IL-4,IL-6, IL-10, IL-18 and TNFα). Individual genotype and haplotype frequencies were compared between cases and controls. Odd ratios were calculated with asymptotic 95% co.. View More»
DOI:
10.4172/2155-9899.1000102