Journal of Hematology & Thromboembolic Diseases
Open Access

Deniz Tugcu

Publications

• Research Article
  Insidious Renal Damage in Patients with Thalassemia Major: Is it More Serious than Appreciated?
  Author(s): Muge Gokce1*, Hatice Kup2, Deniz Tugcu1, Zafer Salcioglu1, Gonul Aydogan1, Arzu Akcay1 and Ferhan Akici1Muge Gokce1*, Hatice Kup2, Deniz Tugcu1, Zafer Salcioglu1, Gonul Aydogan1, Arzu Akcay1 and Ferhan Akici1
  
  Aim: To investigate early renal injury in thalassemia major patients by using novel serum markers and demonstrate the factors leading to renal injury. Material and Methods: Seventy-one thalassemia major patients (37 males) who were on regular transfusion and chelation programme with deferasirox have been enrolled in this study. Thirty-five healthy children of the same age served as a control group. Serum urea-creatinine, electrolytes, cystatin C and glomerular filtration rate were all noted in our cohort and compared with the control group. Proteinuria was also investigated by calculating UPr/UCr ratio. Results: The median serum creatinine level was 0.4 mg/dL (range; 0.2-0.76 mg/dL ) and the median glomerular filtration rate level was 192 mL/min/1.73 m2 (range; 106-308 mL/min/1.73 m2 ) in patients. More than half o.. View More»
  DOI: 10.4172/2329-8790.1000173

  Abstract PDF

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