Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Dewi Yulianti Bisri
Indonesia
Research Article
Serum Interleukin-6 Level after Cyclooxygenase-2 Inhibitor Treatment in
Moderate Traumatic Brain Injury
Author(s): Dewi Yulianti Bisri, Caroline Wullur, Diana Ch Lalenoh and Tatang Bisri
Dewi Yulianti Bisri, Caroline Wullur, Diana Ch Lalenoh and Tatang Bisri
The most clinical scoring of traumatic brain injury patient is Glasgow Coma Scale (GCS) score. Lower GCS score higher IL-6 level and higher morbidity and mortality. Neuroinflammation is one mechanism of secondary brain injury. Selective cyclooxygenase (sCOX-2) inhibitors are drugs commonly used in treatment of postoperative pain but also possess an anti-inflammatory effect. The aim of this study is to determine the role of sCOX-2 inhibitors as inhibitors of inflammatory processes in patients with head injury measured by IL-6.
This is a double blind randomized controlled study involving patients with moderate head injuries who underwent surgery in Dr. Hasan Sadikin Hospital Bandung Indonesia since December 2013 until December 2015. After obtaining approval of research ethics committees from School of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin Hospital, samples were di.. View More»
DOI:
10.4172/2155-6148.1000711