Journal of Leukemia
Open Access

Diane Scholl

Publications

• Research Article
  Barriers to Proceeding to Reduced-Intensity Allogeneic Stem Cell Transplant in Chronic Lymphocytic Leukemia
  Author(s): Samantha M Jaglowski, Susan Geyer, Nyla A Heerema, Patrick Elder, Diane Scholl, John C Byrd, Steven M Devine and Leslie Andritsos Samantha M Jaglowski, Susan Geyer, Nyla A Heerema, Patrick Elder, Diane Scholl, John C Byrd, Steven M Devine and Leslie Andritsos
  
  To identify potential barriers to reduced-intensity conditioning (RIC) allogeneic stem cell transplantation (ASCT) in patients with chronic lymphocytic leukemia (CLL) we performed a retrospective review of patients referred for transplant consultation at our center. Of the 209 patients evaluated, a substantial proportion of patients who were appropriate candidates for RIC-ASCT were unable to attain disease control to proceed (18.3%) with this therapy. Fludarabine resistance at the time of consultation (p=0.026) and the presence of complex karyotype on metaphase cytogenetics (p=0.048) were observed more frequently among patients unable to receive a transplant, suggesting that the timing of transplant evaluation earlier in the course of treatment for high risk genomic patients is critical for being able to incorporate this treatment mod.. View More»
  DOI: 10.4172/2329-6917.1000121

  Abstract PDF

Relevant Topics