Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Dianne Barrett
Tanzania
Case Report
Vigabatrin Retinal Toxicity First Detected with Electroretinographic Changes: A Case Report
Author(s): Dianne Barrett, Jin Yang, Tharikarn Sujirakul and Stephen H. TsangDianne Barrett, Jin Yang, Tharikarn Sujirakul and Stephen H. Tsang
Vigabatrin is an effective antiepileptic drug (AED) typically used in the treatment of refractory partial seizures and infantile spasms. Its use, however, is limited due to the concern of retinal toxicity and subsequent visual field defects. Herewith in we describe a case of vigabatrin toxicity that illustrates electroretinographic (ERG) changes occur before imaging and visual field deterioration. Decrease in maximal ERG b:a ratio was observed before thinning of the retinal nerve fiber layer (RNFL) on optical coherence tomography (OCT)... View More»
DOI:
10.4172/2155-9570.1000363