Journal of Proteomics & Bioinformatics
Open Access

Dimitra Chalkia

Publications

• Research Article
  Phylogenetic Profiles Reveal Structural and Functional Determinants of Lipid-binding
  Author(s): Yoojin Hong, Dimitra Chalkia, Kyung Dae Ko, Gaurav Bhardwaj, Gue Su Chang, Damian B. van Rossum and Randen L. PattersonYoojin Hong, Dimitra Chalkia, Kyung Dae Ko, Gaurav Bhardwaj, Gue Su Chang, Damian B. van Rossum and Randen L. Patterson
  
  One of the major challenges in the genomic era is a nnotating structure/function to the vast quantities of se- quence information now available. Indeed, most of t he protein sequence database lacks comprehensive an nota- tion, even when experimental evidence exists. Furth er, within structurally resolved and functionally a nnotated protein domains, additional functionalities contain ed in these domains are not apparent. To add furthe r complica- tion, small changes in the amino-acid sequence can lead to profound changes in both structure and func tion, underscoring the need for rapid and reliable method s to analyze these types of data. Phylogenetic prof iles pro- vide a quantitative method that can relate the stru ctural and functional properties of proteins, as we ll as their ev.. View More»
  DOI: 10.4172/jpb.1000071

  Abstract PDF

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