Journal of Clinical and Cellular Immunology
Open Access

Dina M Safwat

Publications

• Review Article
  T-regulatory and T-helper type17 Cells Associated Cytokines (IL-35, IL-17) as Potential Diagnostic and Prognostic Biomarkers in Egyptian Acute Myeloid Leukemia Patients
  Author(s): Eman Nasreldin, Dina M Safwat, Hosny B Hamed and Somaia AR Mohamed Eman Nasreldin, Dina M Safwat, Hosny B Hamed and Somaia AR Mohamed
  
  Background: The etiology of acute myeloid leukemia (AML) is heterogeneous and has been associated with several risk factors; tumor escape mechanism is one of the major factors. In this study, we tried to investigate the role of T-reg cells and T- helper cells associated cytokines mainly IL-35, IL-17 in the pathogenesis of AML by determining IL-35 and IL-17 levels in different groups of AML patients. Methods: For this purpose, 70 adult AML patients and 20 healthy controls were studied for IL-35 and IL-17 blood level. From total AML patients 35 were newly diagnosed (ND) patients and 35 patients in complete remission (CR). Results: High levels of IL- 35 and IL-17 were detected in AML patients than the control group and their levels in the ND patients were significantly higher than those patients in CR. There was a significa.. View More»
  DOI: 10.4172/2155-9899.1000478

  Abstract PDF

Relevant Topics