Clinical & Experimental Cardiology
Open Access

Domenica Altavilla

Publications

• Research Article
  RANK-L is a Potential Therapeutic Target in Homogeneous Atherosclerotic Plaques
  Author(s): Federica Galfo, Concetta Zito, Giovanni De Caridi, Luca Longobardo, Mafalda Massara, Scipione Carerj, Maurizio Cusmà-Piccione, Domenica Altavilla, Francesco Squadrito and Alessandra Bitto Federica Galfo, Concetta Zito, Giovanni De Caridi, Luca Longobardo, Mafalda Massara, Scipione Carerj, Maurizio Cusmà-Piccione, Domenica Altavilla, Francesco Squadrito and Alessandra Bitto
  
  Objective and design: The late stages of carotid atherosclerosis are responsible for increased local stiffness, suggesting the need for a therapeutic target that affect either plaque composition and arterial stiffness. There is a lack of data on the role of the local arterial stiffness, assessed by radio-frequency based system and its relationship with the molecular profile of plaques. Subjects: In this study we enrolled 18 consecutive patients undergoing carotid endoarterectomy, with homogeneus or heterogeneous plaques, as established by Doppler-ultrasound and local pulse-wave velocity was assessed before surgery. Methods: In carotid plaque specimens, we evaluated inflammasome (NLRP3), Receptor Activator of Nuclear Factor κB (RANK) and its natural ligand (RANK-L), Osteoprotegerin (OPG), and other inflammatory and .. View More»
  DOI: 10.4172/2155-9880.1000574

  Abstract PDF

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