Cell & Developmental Biology
Open Access

Donato D’Alonzo MD

Publications

• Research Article
  Apoptosis in Bcl2l13 epididymal cells
  Author(s): Donato D’Alonzo MD, Hong Zhang PhDDonato D’Alonzo MD, Hong Zhang PhD
  
  Apoptosis, i.e., controlled cell death, occurs in response to many different environmental stimuli and it plays an indispensable role in the development and maintenance of homeostasis within all multicellular organisms. The apoptotic cascade that occurs within the cell in response to these cues, leads to morphological and biochemical changes that trigger the death of the cell. Bcl2 (B-cell lymphoma 2), encoded in humans by the BCL2 gene, is the founding member of the Bcl-2 family of regulator proteins that regulate cell death (apoptosis), by either inducing (proapoptotic) or inhibiting (anti-apoptotic) apoptosis and thus represents a crucial part in the cascade of cell death. We analyzed the effect of BCL2l13 in murine knockout (k.o.) following apoptosis. These mice show a phenotype in the epididymis; A gland that is prerequisite to guarantee fertility. By inducing apoptosis and there.. View More»
  DOI: 10.4172/2168-9296.1000187

  Abstract PDF

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