Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Douglas M Noonan
Varese, Italy 21100
Italy
Review Article
Polarization of Tumor Infiltrating Leukocytes from Innate Immunity and their role in the Pro-angiogenic Phenotype in NSCLC
Author(s): Lorenzo Mortara, Silvia Zanellato, Barbara Bassani, Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Adriana Albini, Douglas M Noonan and Antonino BrunoLorenzo Mortara, Silvia Zanellato, Barbara Bassani, Andrea Imperatori, Nicola Rotolo, Lorenzo Dominioni, Adriana Albini, Douglas M Noonan and Antonino Bruno
Non-small cell lung cancer (NSCLC), the most frequent lung cancer (80%), can be phenotypically classified into two main subtypes: squamous cell carcinoma (SCC) and adenocarcinoma (ADC). While SCC has relatively rapid doubling times from the onset, ADC has longer doubling times initially that become reduced during tumor progression, suggesting a key role for the microenvironment. During lung tumor progression, a complex and dynamic interplay occurs between proliferating tumor cells and stromal, endothelial and immune tumor-conditioned host cells within the tumor microenvironment (TUMIC). Several factors within the TUMIC, such as hypoxia, cytokines and soluble factors, appear to blunt the anti-tumor immune response and polarize immune cells towards a pro-tumor phenotype. Phenotypically and functionally altered immune cells found in cancer patients include ma.. View More»
DOI:
10.4172/2155-9899.1000312