Journal of Hematology & Thromboembolic Diseases
Open Access

Edward Peres

Publications

• Case Report
  The Inevitable: Donor Derived Chronic Myeloid Leukemia Following Matched Related Stem Cell Transplant for Acute Lymphoblastic Leukemia
  Author(s): Shatha Farhan, Jawad Sheqwara, Brandon Shaw, Susan Michalowski, Milena Cankovic, Edward Peres and Nalini JanakiramanShatha Farhan, Jawad Sheqwara, Brandon Shaw, Susan Michalowski, Milena Cankovic, Edward Peres and Nalini Janakiraman
  
  Donor Derived Cell Leukemia (DCL) is a rare complication of Hematopoietic Stem Cell Transplantation (HSCT).DCL represents a unique form of leukemogenesis in which donor cells become transformed or proliferate followingengraftment in a foreign host environment. We report a 58-year old patient with B-cell acute Lymphocytic leukemia whounderwent an allergenic HSCT from his Human Leukocyte Antigens (HLA)-matched sibling. Three months after HSCT,chromosomal analysis revealed a female karyotype with a (9;22) translocation. This was confirmed with Fluorescencein Situ Hybridization and polymerase chain reaction studies in the recipient and the donor confirming the transmissionof occult leukemia... View More»
  DOI: 10.4172/2329-8790.1000124

  Abstract PDF

Relevant Topics