Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Elena Andreucci
Italy
Review Article
Acidity of Microenvironment as a Further Driver of Tumor Metabolic Reprogramming
Author(s): Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Margheri, Anna Laurenzana, Francesca Bianchini and Lido Calorini
Silvia Peppicelli, Elena Andreucci, Jessica Ruzzolini, Francesca Margheri, Anna Laurenzana, Francesca Bianchini and Lido Calorini
In the last decade, experimental research has intensely focused on metabolic reprogramming of tumor cells, which contributes to cancer cell adaptation and survival in different and hostile microenvironments. Metabolic reprogramming consists of the switch of tumor cells from aerobic or anaerobic glycolysis to oxidative phosphorylation. A comprehensive vision of the metabolic scenario involving functionally different tumor cell subpopulations was proposed as a necessary premise to the design of new strategies of diagnosis and therapy. Special focus has been put on the role of acidosis of certain tumor regions, a very important although frequently neglected aspect.
Despite the progresses in cancer therapy, the escaping of tumor cancer cells from host defense and relapse of disease still represent main issues in tumor-bearing patients. Indeed, malignant cells are provided with a tr.. View More»
DOI:
10.4172/2155-9899.1000485