Journal of Nutrition & Food Sciences
Open Access
ISSN: 2155-9600
ISSN: 2155-9600
Elena Tomeva
Austria
Research Article
EGCG Containing Combined Dietary Supplement Affects Telomeres and Epigenetic Regulation
Author(s): Angelika Pointner, Ulrich Magnet, Elena Tomeva, Elisabeth Dum, Christina Bruckmueller, Christine Mayer, Eva Aumueller and Alexander HaslbergerAngelika Pointner, Ulrich Magnet, Elena Tomeva, Elisabeth Dum, Christina Bruckmueller, Christine Mayer, Eva Aumueller and Alexander Haslberger
Objective: In vitro and in vivo studies in rodents have demonstrated many health promoting properties of individual phytochemicals including antioxidative and chemopreventive effects. Recently combination of substances is claimed to enhance activity. The objective of this study was to investigate health benefits of a daily consumption of a combination of a large variety of phytochemicals (TimeBlock®). To assess potential changes we analyzed specific biomarkers that are associated with aging, oxidative stress and DNA stability: Methylation of LINE-1, c-Myc, IL-6, MLH1, DNTM1, ITGA2B and telomere length. Methods: For this study 110 healthy participants of both sexes between 31-76 years were recruited, 101 subjects were included in further analysis. A small reference group (n=20) without intervention within the same age interval served as control. Participants received a plant ba.. View More»
DOI:
10.4172/2155-9600.1000577