Endocrinology & Metabolic Syndrome
Open Access

Elisa Chierchia

Publications

• Research Article
  Effects of a Combination of Alpha Lipoic Acid and Myo-Inositol on Insulin Dynamics in Overweight/Obese Patients with PCOS
  Author(s): Alessandro D Genazzani, Giulia Despini, Susanna Santagni, Alessia Prati, Erica Rattighieri, Elisa Chierchia and Tommaso SimonciniAlessandro D Genazzani, Giulia Despini, Susanna Santagni, Alessia Prati, Erica Rattighieri, Elisa Chierchia and Tommaso Simoncini
  
  Myo-inositol increases insulin sensitivity in insulin resistant patients with PCOS since it improves the insulin postreceptor pathways. Since previous reports suggested that also alpha lipoic acid has specific positive effects on glucose control, we aimed to evaluate the specific effects of a combination of alpha lipoic acid and myo-inositol on insulin resistance in obese patients with PCOS. We studied a group of obese PCOS patients (n=34, BMI= 30.1 ± 0.9) according to the revised 2003 Rotterdam consensus diagnostic criteria. Among the PCOS patients, 16 out of 34 had diabetic type II relatives (parents and/or grandparents). Patients were administered a combination of alpha lipoic acid (400 mg) and myo-inositol (1 gr.) (Sinopol, Laborest, Italy) every day for at least 12 weeks. Patients underwent to baseline hormone determination and to an oral glucose tolerance test (OGTT.. View More»
  DOI: 10.4172/2161-1017.1000140

  Abstract PDF

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