Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ellen Meijer
England
Research Article
Epstein-Barr Virus Reactivation does not Impact Total T-Cell Reconstitution but is associated with Decreased Functional T Cells after Stem Cell Transplantation
Author(s): Floor L Pietersma, Ingrid MM, Rogier Gaiser, Nening M Nanlohy, Jolanda Scherrenburg, Ellen Meijer and Debbie van BaarleFloor L Pietersma, Ingrid MM, Rogier Gaiser, Nening M Nanlohy, Jolanda Scherrenburg, Ellen Meijer and Debbie van Baarle
Epstein-Barr virus reactivations are frequently observed after allogeneic stem cell transplantation (SCT). We investigated the role of total as well as EBV-specific T-cell reconstitution in relation to onset and severity of EBV reactivation. To this end, 116 patients were prospectively sampled for viral load and absolute T-cell numbers weekly post-SCT during the first 3 months and thereafter monthly until 6 months post-SCT. In addition, we retrospectively analysed EBV-specific T-cell responses in 12 patients during the first year after SCT.In contrast to the general belief, we found that early T-cell reconstitution after SCT does not play a role in the onset of EBV reactivation as numbers of CD4+ and CD8+ T cells during the first 3 months post SCT are similar in patients with or without viral reactivation. However, functional T-cell responses after n.. View More»
DOI:
10.4172/2155-9899.1000342