Journal of Depression and Anxiety
Open Access

El-Mostafi Hicham

Publications

• Research Article
  Argan Oil Supplementation Reverses Anxiety and Depressive-Like Behaviors, Neurodegeneration and Oxidative Stress in Amygdala Induced by Chronic Mild Stress in Rats
  Author(s): El-Mostafi Hicham, Touil Tariq, Laaziz Abderrahim, El-Karouche Bilal, Ouichou Ali, El-Hessni Aboubaker and Mesfioui Abdelhalim El-Mostafi Hicham, Touil Tariq, Laaziz Abderrahim, El-Karouche Bilal, Ouichou Ali, El-Hessni Aboubaker and Mesfioui Abdelhalim
  
  Background: Argan Oil (AO) has been used as a natural remedy in traditional medicine, mainly in Morocco, for several centuries. In this study, we evaluated the beneficial effects of AO dietary on vulnerability of rats to the chronic unpredictable mild stress (UCMS) using behavioral tests, biochemical and histological markers of depression or anxiety. Method: Rats were handled daily (home cage control) or subjected to the UCMS procedure during 6 weeks (i.e., from 43th to 85 Post-natal Day (PND)) (Stress group, n=12). Animals were previously administered orally by NaCl 0.9% (Control group, n=11) or AO (10 ml/kg/day) (AO+Stress group, n=12) for 10 weeks (i.e., from weaning 21th to 93 PND). The efficacy of UCMS or AO dietary on behavioral performances of the animals in the open field, the forced swimming, the light/dark, the novelty suppression of .. View More»
  DOI: 10.4172/2167-1044.1000319

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