Mycobacterial Diseases
Open Access
ISSN: 2161-1068
+44 1478 350008
ISSN: 2161-1068
+44 1478 350008
El-Samahy MH
Egypt
Research Article
Clinico-Mycological Study of Fungal Biofilms in Recalcitrant Onychomycosis
Author(s): Mustafa MR, El-Samahy MH, Diab HM and Bendary SE
Mustafa MR, El-Samahy MH, Diab HM and Bendary SE
Objective: Studying the incidence of different predisposing factors of onychomycosis and the ability of fungal isolates to form biofilms.
Background: Onychomycosis chronicity is referred to difficulties in eliminating the causative pathogens. Biofilms have become focus of era and considered to be one of the globally important causes of chronic recalcitrant infections. Fungi implicated in onychomycosis have the ability to form biofilms ''surface-attached multi-cellular communities''. Biofilm associated fungi acquire higher adaptive ability to overcome stressful conditions, higher antifungal resistance and evasion of host defensive systems. Moreover, they express community-based differential genes and more virulence activities.
Methods: Fifty-four military male patients with onychomycosis were enrolle.. View More»
DOI:
10.4172/2161-1068.1000234