Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
El-Sayed Abdelzaam
Egypt
Research Article
A Comparative Study between Aprepitant only versus Combined Ondansetron and Aprepitant as Antiemetic Therapy, Regarding Efficacy and Duration, in Patients Undergoing Laparoscopic bariatric Surgery Double-blinded, Randomized Control Clinical Trial
Author(s): Ayman Mohamady Eldemrdash Hassan and El-Sayed AbdelzaamAyman Mohamady Eldemrdash Hassan and El-Sayed Abdelzaam
Background: Post-operative nausea and vomiting (PONV) are a common problem associated with general anesthesia. The incidence in high-risk patients can be about 80%.
Objective: The objective was to compare aprepitant versus ondansetron and aprepitant combination antiemetic therapy as regards the efficacy and duration of the combination of dexamethasone-ondansetron as a gold stander and dexamethasone-aprepitant versus dexamethasone-ondansetron-aprepitant in patients undergoing laparoscopic bariatric surgery.
Patients and Methods: A prospective, double-blinded, randomized control clinical trial, for evaluation of 150 laparoscopic bariatric surgery patients receiving a standardized general anesthetic; patients in the dexamethasoneondansetron Group A (Group DO, n=50) received oral placebo identical to aprepitant 2 hours bef.. View More»