Autism-Open Access
Open Access
ISSN: 2165-7890
ISSN: 2165-7890
El-Sheikh MM
Egypt
Research Article
Serum Levels of S100b, Interleukin-6 and Anti-Transglutaminase Ii IgA as Immune Markers in a Sample of Egyptian Children with Autistic Spectrum Disorders
Author(s): Shaker NM, Taha GRA, Kholeif H, Sayed NM, El-Sheikh MM and Abulmagd MLShaker NM, Taha GRA, Kholeif H, Sayed NM, El-Sheikh MM and Abulmagd ML
Background: Autism spectrum disorder (ASD) is a severe neuro-developmental disorder. Various immune components and mediators have been investigated in ASD with controversial results. The purpose of this study was to: 1) investigate the levels of S100B protein (as a marker of neuronal damage), IgA autoantibodies to transglutaminase II (TG2) (as an indicator for presence of autoimmunity) and interleukin 6 (IL-6) (a pro-inflammatory cytokine), in sera of a group of autistic children, 2) explore the relation between serum levels of these parameters and severity of autism, 3) find out if there is any association between serum levels of S100B protein, IL-6 and TG2 IgA which might give clue to their pathogenic role in ASD.
Methods: The levels of S100B protein, IL-6 and TG2 IgA were measured in the sera of 30 autistic children aged from 3 to 14 years... View More»
DOI:
10.4172/2165-7890.1000191