Journal of Clinical Toxicology
Open Access

Emmanuel Uche Olunkwa

Publications

• Research Article
  Atherogenic and Haematologic Indices of Paracetamol- Overdosed Albino Rats Treated With Aqueous Leaf Extracts of Euphorbia Heterophylla and Jatropha Curcas
  Author(s): Chidi Uzoma Igwel, Linus Nwaogu, Emmanuel Uche Olunkwa, Martin Otaba and Viola Onwuliri Chidi Uzoma Igwel, Linus Nwaogu, Emmanuel Uche Olunkwa, Martin Otaba and Viola Onwuliri
  
  Objective: The protective effect of aqueous leaf extracts of Euphorbia Heterophylla and Jatropha Curcas against paracetamol-induced acute changes in lipid, atherogenic and haematologic parameters of albino rats were studied. Methodology: Twenty-five adult male albino rats weighing 180 to 200 g were randomly assigned into 5 experimental groups (I-V) of five animals each. Group I animals were administered 10 ml of distilled water, while group II rats were given 1000 mg/kg paracetamol. Groups III-V were pretreated with vitamin C (500 mg/kg), E. heterophylla (200 mg/kg) and J.curcas (1000 mg/kg) respectively, 1 h before administration of 1000 mg/kg paracetamol. The animals were orally administered the extracts/drugs daily for 14 days. Result: Paracetamol administration reduced significantly (p<0.05) the total choles.. View More»
  DOI: 10.4172/2161-0495.1000344

  Abstract PDF

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