Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Ena Ray Banerjee
Deptartment of Zoology, Immunobiology and Regenerative Medicine Research laboratory,
Kolkata, West Bengal
India
Research Article
Immuno-modulatory and Therapeutic Effect of Curcumin in an Allergensensitized Murine Model of Chronic Asthma
Author(s): Pramathadhip Paul, Sourav Majhi, Shinjini Mitra and Ena Ray Banerjee
Pramathadhip Paul, Sourav Majhi, Shinjini Mitra and Ena Ray Banerjee
Background: Asthma is a chronic allergic disease of the lung and airways, characterized by persistent inflammation and airway hyper-responsiveness. More than 200 million people are affected with severe asthma worldwide. T cells, especially Th2 cells, secreting IL-4, IL-5 and IL-13, are pivotal in orchestrating the disease process. We herein investigated the inhibition mechanism of curcumin, a polyphenol present in turmeric, and its ability to alleviate allergic asthma in C57BL/6J mice.
Methods: Mice were sensitized and challenged with Ovalbumin for 54 days. We investigated cellular infiltration in blood and BALF, assessed levels of serum IgE, assessed structural changes by histological analysis, and determined the levels of expression of relevant genes and proteins.
Results: Our data revealed that curcumin has some anti-.. View More»
DOI:
10.4172/2155-9899.1000551