Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Eric F. Tewalt
Tanzania
Review Article
Regulation of T-cell Tolerance by Lymphatic Endothelial Cells
Author(s): Sherin J. Rouhani, Jacob D. Eccles, Eric F. Tewalt and Victor H. EngelhardSherin J. Rouhani, Jacob D. Eccles, Eric F. Tewalt and Victor H. Engelhard
Lymphatic endothelial cells are most often thought of as structural cells that form the lymphatic vasculature, which transports fluid out of peripheral tissues and transports antigens and antigen presenting cells to lymph nodes. Recently, it has been shown that lymphatic endothelial cells also dynamically respond to and influence the immune response in several ways. Here, we describe how lymphatic endothelial cells induce peripheral T-cell tolerance and how this relates to tolerance induced by other types of antigen presenting cells. Furthermore, the ability of lymphatic endothelial cells to alter immune responses under steady-state or inflammatory conditions is explored, and the therapeutic potential of bypassing lymphatic endothelial cell -induced tolerance to enhance cancer immunotherapy is discussed... View More»
DOI:
10.4172/2155-9899.1000242