Journal of Clinical Toxicology
Open Access

Essam Mahmoud Hafez

Publications

• Research Article
  Protective and Anti-oxidant Activity of the Euryops Arabicus against Paracetamol Induced Hepatorenal Toxicity in Rats
  Author(s): Essam Mahmoud Hafez, Milad Gad Paulis, Mostafa Abotaleb Ahmed, Marian NagyFathy, Ahmed Abdel-Lateff and Mardi M. Algandaby Essam Mahmoud Hafez, Milad Gad Paulis, Mostafa Abotaleb Ahmed, Marian NagyFathy, Ahmed Abdel-Lateff and Mardi M. Algandaby
  
  Paracetamol overdose is a predominant cause of hepatorenal toxicity in both humans and experimental animals. The extract of Euryops arabicus was evaluated for its protective and anti-oxidant effect against paracetamol-induced hepatic and renal injuriesin rats. The extract of Euryops arabicus was administered at100 mg/kg and 200 mg/kg followed by paracetamol at 1g/kg for seven days. The animals were sacrificed after 24 hrs of paracetamol challenge .Indices of liver such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB), serum albumin (SA) and renal indices blood urea (BU) and serum creatinine (SC) were measured. Liver and kidney homogenates were analyzed for oxidative stress biomarkers namely Thiobarbituric acid reactive substances TBARS. Finally, histopathological examinations of both previous organs were examined. Th.. View More»
  DOI: 10.4172/2161-0495.1000227

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