Anesthesia & Clinical Research
Open Access

Esther Abels

Publications

• Research Article
  Sugammadex 4.0 mg kg^-1 Reversal of Deep Rocuronium-Induced Neuromuscular Blockade: A Multicenter Study in Chinese and Caucasian Patients
  Author(s): Buwei Yu, Xiangrui Wang, Hans S Helbo-Hansen, Wen-Qi Huang, Bjarte Askeland, Shitong Li, Zhengnian Ding, Esther Abels, Henk Rietbergen, Tiffany Woo and Philippe PendevilleBuwei Yu, Xiangrui Wang, Hans S Helbo-Hansen, Wen-Qi Huang, Bjarte Askeland, Shitong Li, Zhengnian Ding, Esther Abels, Henk Rietbergen, Tiffany Woo and Philippe Pendeville
  
  Objective: Maintenance of deep Neuro Muscular Blockade (NMB) until the end of surgery may be beneficial in some surgical procedures. The selective relaxant binding agent sugammadex rapidly reverses deep levels of rocuronium-induced NMB. The purpose of this study was to evaluate the efficacy and safety of sugammadex 4.0 mg kg–1 for reversal of deep rocuronium-induced NMB in Chinese and Caucasian patients. Methods: This was an open-label, multicenter, prospective Phase III efficacy study in adult American Society of Anesthesiologists Class 1-3 patients scheduled for surgery under general anesthesia and requiring deep NMB. All patients received intravenous propofol and opioids for induction and maintenance of anesthesia, and a single intubation dose of rocuronium 0.6 mg/kg, with maintenance doses of 0.1-0.2 mg/kg as required. Sugammadex 4.0.. View More»
  DOI: 10.4172/2155-6148.1000408

  Abstract PDF

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