Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Estibalitz Laresgoiti-Servitje
TEC-ABC School of Medicine, American British Cowdray Medical Center,
Carlos Graef Fernández 154-114 Mexico City, 05300
Mexico
Review Article
Pregnancy-Related MiRNAs Participate in the Regulation of the Immune System during the Gestational Period
Author(s): Estibalitz Laresgoiti-ServitjeEstibalitz Laresgoiti-Servitje
Pregnancy is a wonderful and complex example of immunomodulation. The regulation that occurs during pregnancy involves hormones, major histocompatibility molecules, cytokines and different types of cells. Recent evidence shows a significant role for miRNAs in the regulation of the immune system´s cells during the gestational period. Placental miRNAs, found in both normal and complicated pregnancies, are primarily localized in four clusters. These are the chromosome 19-miRNA cluster (C19MC), the miR-371-3 cluster (also on chromosome 19), the chromosome 14-miRNA cluster (M14MC), and the miR-17-92 cluster.
Pregnancy-associated miRNAs may be involved in angiogenesis, trophoblast differentiation, and in the regulation of the immune system. However, their role has not been clearly elucidated. miRNAs hold promise as biomarkers in clinical settings, as altered miRNA expression ma.. View More»
DOI:
10.4172/2155-9899.1000361