Chemotherapy: Open Access
Open Access

Eun-Kyung Jung

Publications

• Review Article
  Synergistic Effect between Baicalein and Antibiotics against Clinic Methicillin and Vancomycin-Resistant Staphylococcus aureus
  Author(s): Young-Soo Lee, Eun-Kyung Jung and Jeong-Dan Cha Young-Soo Lee, Eun-Kyung Jung and Jeong-Dan Cha
  
  Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi, which has long been used in several biological effects, such as antiviral, anti-inflammation, anti-hepatotoxicity, and anti-tumor properties, have been reported. In this study, baicalein demonstrated strong antibacterial activity against clinic isolated methicillin and vancomycin-resistant Staphylococcus aureus (MRSA and VRSA) in this experiment. Baicalein was determined against clinic isolated MRSA 1-16 with MIC and MBC values ranging from 64 to 256 and 64 to 512 μg/ml; for MSSA 1-2 from 128 and 256 μg/ml and 128 and 512 μg/ml; for VRSA 1-2 from 64 and 128 μg/ml and 64 and 512 μg/ml, respectively. The range of MIC50 and MIC90 of baicalein were 16-64 μg/ml and 64-256 μg/ml, respectively. The combination effects of baicalein with antibiotics were synergistic (FIC index <0.5) against most.. View More»
  DOI: 10.4172/2167-7700.1000141

  Abstract PDF

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