Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Eyal Grunebaum
Hospital for Sick Children,
555 University Avenue, Toronto, Ontario M5G 1X8
Canada
Research Article
Gastrointestinal Abnormalities among Patients with Chronic Granulomatous Disease
Author(s): Arnon Broides, Reem Mohammed, Brenda Reid, Chaim M. Roifman and Eyal GrunebaumArnon Broides, Reem Mohammed, Brenda Reid, Chaim M. Roifman and Eyal Grunebaum
Objective: Chronic granulomatous disease (CGD) is characterized by increased susceptibility to infections and inflammation that may lead to various gastrointestinal (GI) abnormalities. Our objective was to better characterize the GI manifestations among patients suffering from CGD as well as the effects of different treatments.Methods: We analyzed 11 patients with CGD managed by the immunology service at the Hospital for Sick Children, Toronto, Ontario between 2000 and 2012.Results: All patients had one or more GI abnormality including colitis (72.7%), peri-anal fissure/abscess (36.3%) or oral aphthous ulcers (36.3%). Failure to thrive occurred in 5 patients (45.4%), all with associated colitis. Bone marrow transplantations (BMT) using HLA-identical sibling donors were performed in 4 patients, with 3 patients surviving. In.. View More»
DOI:
10.4172/2155-9899.1000204