Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Fourati H
Tunisia
Research Article
Replication of Identified Inflammatory Bowel Diseases Genetic Associations: A Case-Control Study in the Tunisian Population
Author(s): Bouzid D, Fourati H, Amouri A, Marques I, Abida O, Tahri N, Penha-Gonçalves C and Masmoudi HBouzid D, Fourati H, Amouri A, Marques I, Abida O, Tahri N, Penha-Gonçalves C and Masmoudi H
Inflammatory bowel diseases (IBD) — Crohn’s disease (CD) and ulcerative colitis (UC) — are chronic gastrointestinal inflammatory disorders with a complex genetic background. A genome wide association scan by the Welcome Trust Case Control Consortium (WTCCC) recently identified several novel susceptibility loci. We performed a replication study in 107 IBD patients (39 CD and 68 UC) and 162 controls. In total, 19 single nucleotide polymorphisms (SNPs) from previously identified susceptibility genes PTPN11, TNF α, IL23R, PTPN2, PTPN22, IL2 and IL10 were studied. In UC, we confirmed the association with PTPN2 (rs254215, GG, P=0.013, Pcorr=0.039; OR= 6.23 (1.18; 32.95)). In CD, we confirmed a marginal association with ((rs11066320, GG, P=0.018, Pcorr=0.054, OR= 0.4 (0.19; 0.82)). No significant association was found at.. View More»
DOI:
10.4172/2155-9899.S10-001