Journal of Clinical and Cellular Immunology
Open Access

Francesca Pregnolato

Publications

• Review Article
  Reactivity against the Five Domains of β₂ Glycoprotein I: A Focus on Systemic Lupus Erythematosus
  Author(s): Cecilia Beatrice Chighizola, Maria Orietta Borghi, Claudia Grossi, Francesca Pregnolato, Maria Gerosa and Pier Luigi Meroni Cecilia Beatrice Chighizola, Maria Orietta Borghi, Claudia Grossi, Francesca Pregnolato, Maria Gerosa and Pier Luigi Meroni
  
  Beta-2 glycoprotein I (β2GPI) is the main antigenic target for antiphospholipid antibodies (aPL), the serological markers of antiphospholipid syndrome (APS), a systemic autoimmune disease characterized by vascular thrombosis and/or pregnancy morbidity. aPL are detected in 20 to 50% of patients with systemic lupus erythematosus (SLE), representing a poor prognostic factor. Indeed, thrombotic events heralds high morbidity and mortality, being regarded as the strongest predictors of death in the first five years after SLE onset. It would be thus very important to identify a reliable laboratory tool such as anti-domain antibodies to better risk-stratify lupus patients according to the aPL profile, in order to tailor treatment strategies. Domain I (DI) of β2GPI has lately been identified as the main epitope targeted by antibodies reacting against β.. View More»
  DOI: 10.4172/2155-9899.1000206

  Abstract PDF

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