Chemotherapy: Open Access
Open Access

Francesca Ridolfi

Publications

• Research Article
  Paclitaxel and Bevacizumab in First Line-Treatment Patients with HER-2 Negative Advanced Breast Cancer: Who could Benefit?
  Author(s): Mirco Pistelli, Zelmira Ballatore, Mariagrazia De Lisa, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi and Stefano Cascinu Mirco Pistelli, Zelmira Ballatore, Mariagrazia De Lisa, Miriam Caramanti, Alessandra Pagliacci, Nicola Battelli, Francesca Ridolfi, Alfredo Santinelli, Tommasina Biscotti, Rossana Berardi and Stefano Cascinu
  
  Background: Angiogenesis is essential for tumor growth and development of metastases in human breast cancer. Randomized studies have shown that bevacizumab (inhibitor of VEGF) combined with taxane-based regimens increases response rates and prolongs Progression-Free Survival (PFS) of patients with Metastatic Breast Cancer (MBC). However predictive or prognostic markers that identify the appropriate target population, thus improving the cost-effectiveness ratio of this treatment, are still needed. In this retrospective analysis, we investigated the impact of traditional clinical and pathological features in order to identify the subgroups of patients who derive the greatest benefit from antiangiogenic-agents. Patients and methods: Retrospectively, we included consecutive patients treated with bevacizumab (10 mg/Kg on days 1 and 15) and paclitaxel (90 mg/m2, on days 1, 8 and 15) as first-l.. View More»
  DOI: 10.4172/2167-7700.1000127

  Abstract PDF

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