Journal of Proteomics & Bioinformatics
Open Access

Frank Graziano

Publications

• Research Article
  Genetic Mutations Affecting the Success and Failure of HIV Regimens
  Author(s): George Towfic, Judy Munshower, Samira Kettoola, Fadi Towfic, Frank Graziano, John Viner and Helena TsotsisGeorge Towfic, Judy Munshower, Samira Kettoola, Fadi Towfic, Frank Graziano, John Viner and Helena Tsotsis
  
  Recently, genotypic testing (the identification of viral mutations and their associated drug resistance) has be- come a popular procedure to identify drug resistanc e before advising alternative therapy regimens. Since major drug resistance factors are associated with the frequency of viral mutations, many researchers have explored HIV’s mutation frequency at specified nucl e- otide sequence positions in response to different t ypes of drug therapy. However, only a handful of papers dis- cuss major genetic signatures that lead to positive pa- tients’ responses to a specific type of drug therap y. Using existing clinical drug resistance libraries, we were able to determine the most common mutations in the HIV protease (PR) enzymes associated with the s uc- cess and failure of Protease Inhibitor (PI) .. View More»
  DOI: 10.4172/jpb.1000097

  Abstract PDF

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