Journal of Probiotics & Health
Open Access
ISSN: 2329-8901
ISSN: 2329-8901
Frans Rutten
England
Research Article
The Effect of Probiotic Lactic Acid Bacteria (LAB) Strains on the Platelet Activation: A Flow Cytometry-Based Study
Author(s): Khalil Azizpour, Kok van Kessel, Ruud Oudega and Frans Rutten
Khalil Azizpour, Kok van Kessel, Ruud Oudega and Frans Rutten
Platelet-activation and agonist-induced platelet aggregation process to the pathogenesis of Infective Endocarditis (IE), bacteremia symptoms or other thrombotic complications and cardiovascular diseases. Activation of platelets by probiotic lactic acid bacteria strains is considered as thrombotic initiative factor contributing to the development and progression of Lactobacillus endocarditis. The main purpose of the current study was to evaluate the immunologic enhancement effect of probiotic strains L. plantarum, L. acidophilus and L. rhamnosus on the activation of blood platelets. Whole fresh blood flow cytometry was used to measure p-selectin expression and fibrinogen binding at basal levels and following stimulation with platelet agonists and probiotic lactic acid bacteria strains. Platelet activation was determined by labelling.. View More»
DOI:
10.4172/2329-8901.1000185