Emergency Medicine: Open Access
Open Access

Frederico Raposo

Publications

• Research Article
  HMGB-1 Levels May be Markers of Haematological Dysfunction after Severe Trauma
  Author(s): António Sousa, Jose Artur Paiva, Sara Fonseca, Luís Valente, Frederico Raposo, Moura Gonçalves and Luis de Almeida António Sousa, Jose Artur Paiva, Sara Fonseca, Luís Valente, Frederico Raposo, Moura Gonçalves and Luis de Almeida
  
  Introduction: HMGB-1 is a nuclear protein that acts as an alarmin to tissue repair in sepsis and is one of multiple mediators in the systemic inflammatory response (SIRS). Its role in clinical models of severe trauma is less well studied. Objectives: The aim of this study was to study the release pattern of HMGB-1 in the first 72 hours after severe trauma and the association of HMGB-1 levels with tissue damage, shock, coagulation disorders and thrombocytopenia. Materials and methods: A prospective cohort study enrolling all adult trauma patients with injury severity score (ISS)>15 admitted to a Trauma Room. Analytical variables assessed were: creatine kinase (CK), myoglobin (MIO) lactate, coagulation times and platelets at admission; HMGB-1 levels were measured at admission 24, 48 and 72h. Results: .. View More»
  DOI: 10.4172/2165-7548.1000288

  Abstract PDF

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