Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Fumihiro Tanaka
Japan
Research Article
Indoleamine 2,3-Dioxygenase as A Prognostic Factor in Patients with Non-Small Cell Lung Cancer
Author(s): Takeshi Hanagiri, Misako Fukumoto, Yukiko Koyanagi, Yukari Furutani and Fumihiro TanakaTakeshi Hanagiri, Misako Fukumoto, Yukiko Koyanagi, Yukari Furutani and Fumihiro Tanaka
Background: Indoleamine 2,3-dioxygenase (IDO) is an immunomodulatory enzyme produced by tumor cells and some alternatively activated macrophages and other immunoregulatory cells. The purpose of the present study was to evaluate the prognostic value of the relative expression of the forkhead/winged helix transcription factor 3 (Foxp3) and IDO in non-small cell lung cancer (NSCLC) tissues.Methods: The NSCLC tissues from 141 patients who underwent complete surgical resection were collected at the time of surgery. The relative expression levels of Foxp3 and IDO in the tissues were determined by quantitative RT–PCR.Results: The histological types of cancer seen in these patients included 105 adenocarcinomas, 24 squamous cell carcinomas and 12 other types of carcinoma. The average expression levels of Foxp3 and IDO relativ.. View More»
DOI:
10.4172/2155-9899.1000260