Journal of Hematology & Thromboembolic Diseases
Open Access

Fumio Kawano

Publications

• Research Article
  Clinical Value of Serum Soluble CD30 Levels in Adult T-Cell Leukemia/ Lymphoma
  Author(s): Ratiorn Pornkuna1, Shigeki Takemoto1,2*, Michihiro Hidaka2, Fumio Kawano2 and Yoshio Haga1,3Ratiorn Pornkuna1, Shigeki Takemoto1,2*, Michihiro Hidaka2, Fumio Kawano2 and Yoshio Haga1,3
  
  Adult T-cell leukemia/lymphoma (ATLL) is an incurable neoplasm of mature T-cells with a median survival time of approximately one year. The aim of this study was to compare the clinical value of soluble CD30 (sCD30) levels with soluble IL-2 receptor α chain (sIL-2R) levels in two different clinical settings of ATLL patients; before an initial therapy of chemotherapy or gastric resection (n=32), and before allogeneic hematopoietic stem cell transplantation (HSCT; n=24). All patients completed the 2-year follow-up. Both sIL-2R (p=0.016) and sCD30 (p=0.030) levels were significant predictors of overall survival before the initial therapy. The number of ATLL cells in peripheral blood (PB) was correlated with sCD30 levels (Spearman’s correlation coefficient, ρ=0.46; p=0.009) but not with sIL-2R levels (ρ=0.16; P=0.38). Patients who survived for longer than two years, an.. View More»
  DOI: 10.4172/2329-8790.1000167

  Abstract PDF

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