Journal of Applied Pharmacy
Open Access

Ghare JL

Publications

• Research Article
  Evaluation of Novel Polymer in the Development of Floating In situ Gelling System
  Author(s): Ghare JL and Mundada ASGhare JL and Mundada AS
  
  The objective of this work was to assess the new polymer obtained from natural source (Helianthus annuus) in the formation of floating in situ gel of Ranitidine HCl. Low Methoxy Pectin (LMP), calcium carbonate, sodium citrate, D-mannitol, methylparaben and propylparaben were utilized in developing floating in situ gelling formulations. The developed formulations were evaluated for various physicochemical properties like viscosity, floating lag time, and duration of floating, in vitro gelation and in vitro drug release. The 32 full factorial design was applied wherein concentration of LMP and calcium carbonate were considered as independent variables whereas floating lag time and drug release after 8 h (Q8 ) were taken as dependent variables. All formulations (F1–F9) exhibited floating within 60 s and remained floated for around 24 h. All the formulations were pourable before co.. View More»
  DOI: 10.21065/1920-4159.1000238

  Abstract PDF

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