Journal of Developing Drugs
Open Access

Ghule MM

Publications

• Research Article
  Formulation and Evaluation of Modified Liposome for Transdermal Drug
  Author(s): Ghule MM and Bhoyar GSGhule MM and Bhoyar GS
  
  Objective: Pramipexole is widely used in the treatment of anti-Parkinson’s, however it is associated with several side effects so the objective was to develop liposomal drug delivery of Pramipexole and thus reduce its side effect and toxicity and improve bioavaibility, efficacy and therapeutic index. Further study to modify drug delivery and to determine effect of stearylamine and sodium cholate content on the liposomal characteristics was investigated. Methods: In the present study the modified liposomes were prepared by using Pramipexole, phosphotidylcholine, cholesterol, stearylamine and sodium cholate in different ratio. These liposomes were prepared using thin film hydration method and characterized for vesicle size, drug entrapment studies, in-vitro release, and zeta potential, ex-vivo study. Results: The preparation of pramipexole loaded liposome was initiated by studying .. View More»
  DOI: 10.4172/2329-6631.1000186

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