Journal of Clinical Toxicology
Open Access

Gilles Hanton

Publications

• Research Article
  Echocardiography a Non-Invasive Method for Investigating Preclinical Drug Toxicity and Safety
  Author(s): Gilles HantonGilles Hanton
  
  Echocardiography (EC) is a method used for investigating cardiac morphology and function. Two-dimensional EC gives a visualization of the morphology of the heart. M-mode EC allows heart function to be monitored. Pulsed Doppler EC is the method of choice for measuring blood flows through valves and large vessels. EC is used in routine in clinic and veterinary practice but is infrequently applied to preclinical evaluation of drug toxicity and safety pharmacology despite a number of advantages. Since similar investigations can be done in laboratory animals and humans, preclinical and clinical findings can easily be transposed to each other. EC is totally non-invasive, it does not induce any suffering to the animals and has no impact on health and physiology. It allows repeated measurements and consequently monitoring of development and evolution of adverse effects. In this way, EC evalua.. View More»
  DOI: 10.4172/2161-0495.1000200

  Abstract PDF

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