Journal of Clinical Toxicology
Open Access

Gilles Hanton

Publications

• Research Article
  Improvement of QT analysis for Evaluating the Proarrhythmic Risk of Drug: The Importance of Spatial and Temporal Dispersion of Repolarization
  Author(s): Gilles HantonGilles Hanton
  
  Cardiac arrhythmias, in particular life-threatening Torsades de Pointes (TdP) are serious adverse effects associated with a number of pharmaceuticals belonging to different classes. It is therefore critical to have reliable biomarkers for assessing this risk during pre-clinical testing of new compounds. Prolongation of cardiac action potential and consequently of the QT interval of the ECG is generally considered as indicative of a risk of arrhythmia. Evaluation of drug effects on QT in preclinical studies is therefore requested by ICH (International Conference on Harmonization) guideline (S7B). However there is now growing evidence that the prolongation of mean QT interval is not an accurate indicator of the risk of arrhythmia and that other parameters of cardiac repolarization are more predictive. They include instability of action potential duration and increase in transmural heter.. View More»
  DOI: 10.4172/2161-0495.1000202

  Abstract PDF

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