Endocrinology & Metabolic Syndrome
Open Access

Giridharan Nappanveettil

Publications

• Review Article
  The Impact of Obesity on Immune Response to Infection and Vaccine: An Insight into Plausible Mechanisms
  Author(s): Prathibha Bandaru, Hemalatha Rajkumar and Giridharan NappanveettilPrathibha Bandaru, Hemalatha Rajkumar and Giridharan Nappanveettil
  
  Though we know much about development of obesity and its associated complications like type II diabetes, cardiovascular diseases, hypertension and cancer, our knowledge is very limited about the impact of this metabolic syndrome on immune functions per se. Studies in obese humans and animal models have earlier shown, altered lymphocyte numbers, and reduced lymphocyte responsiveness to mitogen stimulation, dysregulated cytokine expression, decreased natural killer cells, macrophage and dendritic cell functions, leading to reduced resistance to infections involving a number of organisms such as Mycobacterium tuberculosis, Coxsackie virus, Helicobacter pyroli and influenza. Several obesity-associated hormonal changes such as leptin resistance, hyperinsulinemia, and metabolic changes such as excessive inflammation and altered glucose, amino acid and fatty acid metabolism which are require.. View More»
  DOI: 10.4172/2161-1017.1000113

  Abstract PDF

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