Endocrinology & Metabolic Syndrome
Open Access

Gisele Facholi Bomfim

Publications

• Review Article
  The Toll way to hypertension: role of the innate immune response
  Author(s): Gisele Facholi Bomfim, Theodora Szasz, Maria Helena C. Carvalho and R. Clinton WebbGisele Facholi Bomfim, Theodora Szasz, Maria Helena C. Carvalho and R. Clinton Webb
  
  The involvement of pro-inflammatory processes in cardiovascular disease such as hypertension is a well accepted concept. Human hypertension is associated with increased levels of circulating cytokines and their participation in the associated target organ damage has clearly been demonstrated. Recent evidence suggests that at least in animal models of hypertension, components of the adaptive immune system such as T cells are activated and infiltrate target organs, promoting inflammation and thus participating in the maintenance of increased blood pressure. However there is a paucity of information on the role of the innate immune response in hypertension. Moreover, the identity of the original stimuli responsible for the immune system activation as well as the chronology of these events during hypertension pathogenesis is unknown. The current paradigm is that the immune system is a.. View More»
  DOI: 10.4172/2161-1017.1000117

  Abstract PDF

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