Journal of Proteomics & Bioinformatics
Open Access

Glen R. Couchman

Publications

• Research Article
  SERPINE 1 Links Obesity and Diabetes: A Pilot Study
  Author(s): Punit Kaur, Michael D. Reis, Glen R. Couchman, Samuel N. Forjuoh, John F. Greene Jr and Alexzander Asea Punit Kaur, Michael D. Reis, Glen R. Couchman, Samuel N. Forjuoh, John F. Greene Jr and Alexzander Asea
  
  In the past decade there has been a dramatic increase in the number of Americans considered obese. Over this same period, the number of individuals diagnosed with diabetes has increased by over 40%. Interestingly, in a great number of cases individuals considered obese develop diabetes later on. Although a link between obesity and diabetes has been suggested, conclusive scientific evidence is thus far just beginning to emerge. The present pilot study is designed to identify a possible link between obesity and diabetes. The plasma proteome is a desirable biological sample due to their accessibility and representative complexity due, in part, to the wide dynamic range of protein concentrations, which lead to the discovery of new protein markers. Here we present the results for the specific depletion of 14 high-abundant proteins from the plasma samples of obese and diabe.. View More»
  DOI: 10.4172/jpb.1000139

  Abstract PDF

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