Journal of Clinical and Cellular Immunology
Open Access

Godfrey Grech

Publications

• Review Article
  The Influence of Innate and Adaptive Immunity on Crohn’s Disease Severity
  Author(s): Neville Azzopardi, Keith Sacco and Godfrey GrechNeville Azzopardi, Keith Sacco and Godfrey Grech
  
  Stricturing and penetrating disease are classified as severe Crohn’s disease types and are frequently associated with an increased risk for bowel surgery. Research has shown that early treatment with aggressive immunosuppression (including biological and thiopurine therapies – the so-called “top-down approach”) results in a diminished risk of developing these complicated disease types. However, these therapies carry significant risks and cost. Being able to predict which patients are at an increased risk of developing severe Crohn’s disease may enable us to treat patients individually, with the aggressive “top-down approach” started at diagnosis in patients with a significantly increased risk of developing complicated disease types. Defects of innate and adaptive immunity both play a role in Crohn’s disease pathophysiology. Identifying w.. View More»
  DOI: 10.4172/2155-9899.1000219

  Abstract PDF

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