ISSN: 2329-9509
+44 1478 350008
Gokhan Ozgen
Turkey
Research Article
Efficacy of Zoledronic Acid Treatment in Paget Disease of Bone
Author(s): Emine Kartal Baykan, Sevki Cetinkalp, Gokhan Ozgen and Candeger YilmazEmine Kartal Baykan, Sevki Cetinkalp, Gokhan Ozgen and Candeger Yilmaz
Purpose: Paget disease is a disease of bone of unknown etiology with increased bone turnover that results in defective bone microarchitecture and bone deformity. Bisphosphonates are used in symptomatic Paget disease of bone. Clinical trials have shown that zoledronic acid was more effective than other bisphosphonates in treatment of Paget disease.
Methods: In this study, we retrospectively reviewed the remission and relapse statuses of 12 patients with Paget disease of bone, who were seen as outpatients between October 2011 and October 2013. We evaluated alkaline phosphates, osteocalcin, deoxypyridinoline levels measured before and at 6th, 12th, 18th months of treatment.
Results: Pretreatment values for alkaline phosphates, deoxypyridinoline, osteocalcin were as follows; 473 ± 256 .. View More»
DOI:
10.4172/2329-9509.1000120