Endocrinology & Metabolic Syndrome
Open Access

Golubovska OA

Publications

• Research Article
  Experience of Using Metformin in Patients Infected with HCV Genotype 3 with Concomitant Metabolic Disorders
  Author(s): Golubovska OA, Gerasun BA, Shkurba AV, Kulyesh OV and Bezrodna OV Golubovska OA, Gerasun BA, Shkurba AV, Kulyesh OV and Bezrodna OV
  
  Summary: The so-called “metabolic syndrome” is among the most significant factors that influence the natural course of Chronic Hepatitis C (CHC) and the effectiveness of specific Antiviral Therapy (AVT). Materials and methods: 34 patients with chronic hepatitis C (genotype 3) treated with standard AVT (PEGylated interferon in combination with ribavirin) were included in the study. The study group included 18 patients with chronic hepatitis C in combination with metabolic disorders, namely the Insulin Resistance (IR). They received metformin 20 mg/kg for 24 weeks. The control group included 16 patients with chronic hepatitis C and IR, who did not receive metformin. The patients’ age (35.7 ± 1.5) and sex prevalence were matched in both groups. The diagnosis criteria of CHC included: clinical and laboratory signs of the.. View More»
  DOI: 10.4172/2161-1017.1000163

  Abstract PDF

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