Journal of Drug Metabolism & Toxicology
Open Access

Gomase VS

Publications

• Research Article
  Prediction of Antigenic MHC Peptide Binders and TAP Binder of COX1 Protein through In Silico Approach
  Author(s): Mishra S and Gomase VS Mishra S and Gomase VS
  
  In the current analysis Cytochrome c oxidase subunit I (CO1 or MT-CO1) protein sequence from GWD has been used to study the MHC binding antigenic peptide, antigenic peptide prediction through different B cell prediction method, protein solvent accessibility, polar and nonpolar residue to analyze the regions which are probably exposed on the protein surface. From the protein the peptide fragment can be used to analyze and specific nonamer can be selected for the rational vaccine designing. In this investigation, PSSM and SVM algorithms are applied for finding of MHC I and MHC II binding peptides. We also predicted the high affinity TAP binding peptides of CO1 protein from GWD, having 205 amino acids which show 197 nonamers. From the opted outcomes we predict that, the possibilities that, the antigenic peptide of cytochrome c oxidase subunit I (mitochondrion) protein might play a major rol.. View More»
  DOI: 10.4172/2157-7609.1000201

  Abstract PDF

Relevant Topics