Lupus: Open Access
Open Access

Gorelik G

Publications

• Research Article
  Protein Phosphatase 5 Contributes to the Overexpression of Epigenetically Regulated T-Lymphocyte Genes in Patients with Lupus
  Author(s): Patel D, Gorelik G, Richardson BPatel D, Gorelik G, Richardson B
  
  Objective: Lupus develops when genetically predisposed people encounter certain drugs or environmental agents causing oxidative stress such as infections and sun exposure, and then typically follows a chronic relapsing course with flares triggered by the exogenous stressors. Current evidence indicates that these environmental agents can trigger lupus flares by inhibiting the replication of DNA methylation patterns during mitosis in CD4+ T cells, altering the expression of genes suppressed by this mechanism that convert normal “helper” cells into auto reactive cells which promote lupus flares. How environmental stressors inhibit T cell DNA methylation though is incompletely understood. Protein phosphatase 5 (PP5) is a stress induced inhibitor of T cell ERK and JNK signaling in “senescent” CD4+CD28- T cells, also characterized by DNA demethylatio.. View More»
  DOI: 10.35248/2684-1630.16.1.120

  Abstract PDF

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